Friday, December 17, 2010

Lung Oxygen Measurement / artifical lung

Oxygen MeasurementMeasure Trace & Percent Oxygen Contact Alpha Omega Instrumentswww.aoi-corp.com
An artificial lung for humans and other mammals inserted within the body or placed externally. The artificial lung comprises an electrically actuated three-way valve, a casing containing parallel loops of oxygenator tubes for oxygenation of blood by an atmosphere of circulating air, and an air circulation driving fan powered by an energizing system. As a safety factor in the event of leakage in the casing, a check valve is inserted in an effluent blood duct from the casing to the aerated effluent blood. Two artificial lungs can be utilized internally as left and right lungs.

 
 
 
 
Artificial lung device  United States Patent 6723132
 
 
 
 

Thursday, December 16, 2010

ECMO used for infants



ECMO stands for Extra Corporeal Membrane Oxygenation. ECMO is used in infants who are extremely ill due to breathing or heart problems. The ECMO machine circulates blood through an artificial lung back into the bloodstream. This provides adequate oxygen to the baby while allowing time for the lungs and heart to "rest" or heal.

see source at...
http://www.edward.org/body.cfm?xyzpdqabc=0&id=223&action=detail&AEArticleID=19844&AEProductID=Adam2004_1&AEProjectTypeIDURL=APT_2

Wednesday, December 15, 2010

Lung implant is a breath of fresh air

Lung implant is a breath of fresh air December 2010







Artificial lung technology could reduce the death rate for patients awaiting a lung transplant, say US scientists.

Advanced lung disease is characterised by an inability to remove carbon dioxide from the blood and reduced oxygen uptake efficiency. A shortage of donors can mean long delays and high mortality rates for those awaiting a transplant. The only technology available to aid sufferers during this time is based in intensive care units, hindering quality of life.

Now, Joseph Vacanti and coworkers at Massachusetts General Hospital, Boston, have developed a device that achieves the CO2/O2 gas exchange that, when implanted in the body, could allow patients more freedom when awaiting a transplant. Their design is a microfluidic branched vascular network through which blood flows, separated from a gas-filled chamber by a silicone membrane less than 10um thick. The network is formed by casting polydimethylsiloxane, a biocompatible polymer, on a micro machined mould.

A device that achieves carbon dioxide/oxygen gas exchange could allow patients more freedom when awaiting a lung transplant

A major challenge faced by Vacanti's team was achieving a blood pressure within the device's channels similar to that in veins and arteries. They applied computational fluid dynamics to optimise the vascular network's structure to avoid clotting induced by excessive blood pressure. 'Fulfilment of these design criteria necessitated creating channels that had variable depth throughout the network and also had precise curvature,' says Vacanti's coworker, David Hoganson.

Vacanti's device could be scaled up for implantation. According to Hoganson, an implant-sized device could be fabricated by 'stacking the functional layers of the device to achieve the necessary surface area for gas exchange'.

Jaisree Moorthy, who specialises in using microfluidics in tissue engineering at the University of Pennsylvania, says that Vacanti's device provides a very elegant solution. Compared to existing devices, Moorthy comments that it 'is more efficient due to a thinner membrane, and mimics the biological CO2/O2 transfer rate'.

In the future, Vacanti hopes to develop the device further to incorporate engineered lung tissue.

Link to journal articleLung assist device technology with physiologic blood flow developed on a tissue engineered scaffold platform

David M. Hoganson, Howard I. Pryor II, Erik K. Bassett, Ira D. Spool and Joseph P. Vacanti, Lab Chip, 2011

DOI: 10.1039/c0lc00158a


Now, Joseph Vacanti and coworkers at Massachusetts General Hospital, Boston, have developed a device that achieves the CO2/O2 gas exchange that, when implanted in the body, could allow patients more freedom when awaiting a transplant.


ChemScience Volume 2010 12 lung implant breath fresh air click to see source

see more info on this lung implant method procedure

Tuesday, December 14, 2010

MORE COPD PATIENTS COULD BENEFIT FROM OXYGEN THERAPY

MORE COPD PATIENTS COULD BENEFIT FROM OXYGEN THERAPY

The website 6-minutes, a daily newsletter for Australian doctors, reports on a study that finds many patients ineligible for supplemental oxygen under current criteria could still benefit from oxygen therapy. They conclude that a single daytime measurement of oxygen in the blood may not be the best method of determining who could benefit from oxygen therapy. Researchers find a large number of people are okay during the day, but have oxygen saturations below 90 percent at night. For more information, see:

More COPD patients could benefit from oxygen

Many COPD patients with borderline hypoxaemia would benefit from long term oxygen therapy but are currently excluded due to misleading one-off measurements of oxygenation, Victorian researchers say.

A study of 35 COPD patients with moderate hypoxaemia on resting showed that 24-hour oximetry was able to identify a large subgroup of patients who had clinically significant hypoxaemia throughout the day and especially at night.

The use of ambulatory oximetry showed that 54% of patients spent more than 30% of the monitoring period with oxygen saturation below 90%, “suggesting a significant degree of hypoxaemia that is often missed by point measurement of PaO2,” say the researchers from Barwon Health in the Internal Medicine Journal (online 1 December) .

“We believe this group may include patients with the potential to benefit from this therapy [despite] being ineligible for prescription of long term oxygen therapy according to current criteria,” they write.

The study authors say long term oxygen therapy is known to improve survival, pulmonary dynamics and exercise capacity in patients with severe hypoxaemia, but currently eligibility for oxygen therapy is decided by point measurement of PaO2.

The study also showed that BMI was correlated with daytime hypoxaemia, whereas age and PaO2 were the only significant predictors of nocturnal hypoxaemia.

“Our findings suggest that a single daytime measurement of resting PaO2 may not be the optimal method for determining which patients will benefit from this approach to nocturnal oxygen prescription,” they say.

By Michael Woodhead

New lung disease network to benefit patients and boost UK economy

New lung disease network to benefit patients and boost UK economy



Scientists and clinicians in Nottingham are to work more closely with industry to develop new ways of diagnosing and treating lung disease.

Nottingham has been chosen as one of just nine centres across the UK to host a Government-spearheaded ‘Therapeutic Capability Cluster’, which aims to forge closer links between academia, the NHS and the life sciences industry to speed up the process of getting new drugs from lab bench to bedside.

The new cluster will draw on the world-leading research expertise of scientists at The University of Nottingham and clinical excellence of Nottingham University Hospitals NHS Trust to help pharmaceutical companies develop clinical trials for potential new treatments for a range of respiratory diseases.


see more at...
http://www.nottingham.ac.uk/news/pressreleases/2010/december/lungdiseasenetwork.aspx

Wednesday, December 8, 2010

U.S. servicemember survive having a lung removed downrange

Doctors say Griego — of Apache Troop, 1st Squadron, 75th Cavalry Regiment, 101st Airborne Division — is also the first U.S. servicemember in the Iraq and Afghanistan wars to survive having a lung removed downrange.

His journey back started with the brave actions of his fellow soldiers. Griego and his unit were securing a road in southern Afghanistan on Oct. 19 when Taliban fighters opened fire from a nearby building. Griego was shot in the chest, and blood spewed from a bullet wound under his right ribs. Sgt. Matt Casting and Sgt. Mark Reed stanched it, keeping Griego from hemorrhaging, the most common cause of combat death.

Then, amid the heated firefight, the unit’s medic, Spc. Allan Hughes, ran 650 meters to reach Griego, who was laboring to breathe because air was building in his lung cavity, putting pressure on his lungs to the point of near collapse. Hughes thrust a thick, long needle into Griego’s chest, relieving the pressure and saving his life yet again.

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Minutes later, Griego was evacuated to the Role 3 hospital in Kandahar. There doctors discovered a tiny wound near the left side of Griego’s neck. This told them that the bullet had torn through his chest cavity, likely injuring both lungs, said U.S. Navy Dr. (Cmdr.) Eric Elster, director of surgical services at the hospital.

They wheeled Griego into the operating room. Elster and a team of surgeons searched for the severed vessels that poured blood into Griego’s lungs. They stapled off the top of Griego’s left lung, stemming the bleeding there.

But his right lung was full of holes. Despite their best efforts to stop all the leaks, the doctors could not control the bleeding, Elster said. So the surgeons clamped off the blood flow to the right lung, ensuring that it would have to be removed later.

A CT scan showed the bullet’s path through Griego’s chest. It had punctured his right chest near his back and then ricocheted off his spine — somehow not injuring it — and out the top of his left neck.

“He did have injuries to both his lungs,” Elster said. “But this was kind of a lucky shot, in that he did not have any other injuries to his spinal cord or esophagus that would have magnified it.”

The next morning surgeons removed Griego’s right lung, a procedure rarely attempted downrange. They also called Landstuhl Regional Medical Center’s Lung Rescue Team, which flies to combat zones and retrieves servicemembers with serious lung injuries.

The lung team landed in Kandahar that afternoon and tried several different ventilators on Griego, attempting to force air into his remaining lung to make him stable for flight. But all the ventilators failed, and Dr. (Lt. Col.) Sandra Wanek, who led the combat evacuation mission, chose to use a portable heart-lung machine that performs a therapy called extracorporeal membrane oxygenation, or ECMO.

The device, about the size of a suitcase, forces the blood through an artificial membrane that lets in oxygen while taking out carbon dioxide — mimicking the trade-off that naturally takes place in the lungs. The machine worked even better than Wanek expected, and by the time the team landed at Landstuhl several hours later on Oct. 20, Griego’s condition had started to improve.

He was then flown to the university hospital in Regensburg, Germany, where doctors have particular expertise with the portable ECMO machine. Doctors there had also trained Wanek and her team how to use the device in July.

Developed in the 1980s as a way to save the lives of premature infants with underdeveloped lungs, ECMO was never formally approved as a therapy in the United States because the machine was used only as a last-ditch, life-prolonging measure. Recently, however, ECMO machines have been used to treat patients with lung failure, including H1N1 influenza patients, with better prognoses.

Maquet, the company that developed the portable ECMO machine, is trying to get it approved for broader use in the U.S., particularly with patients suffering lung or heart failure who need to be transported.

A ruling by the U.S. Food and Drug Administration is expected sometime next year, but Wanek said she knows what would have happened to Griego had he received same gunshot wound stateside.

“This happens to you in Los Angeles,” she said, “ and the mortality rate is about 70 percent.”

A ventilator, Wanek explained, pushes air into the lungs, but that process can further injure, or even kill, patients whose lungs are damaged and weak.

The ECMO machine bypasses the lungs entirely. At the Regensburg hospital, Griego was kept sedated as the machine controlled the oxygen and carbon dioxide in his bloodstream. His remaining lung was left to heal.

There, Peter Griego read to his son from several hunting magazines, telling him about the latest rifles and archery bows — unsure whether they would again go hunting for deer and elk in mountains a few hours from their home in Mesa, Ariz. A weak squeeze of the hand was the only indication that his son could hear him. But Griego’s remaining lung slowly recovered, and doctors started forcing it to take “baby breaths,” Wanek said.

“As the lung was doing better,” she said, “we were able to let the lung do a little more, and the machine do a little less.”

After more than two weeks at the Regensburg hospital, Griego was taken off the ECMO machine. He returned to Landstuhl, where his tracheotomy tube was also removed, allowing him to talk in whispers when his father held two fingers over his open windpipe.

In Landstuhl’s intensive care unit, Griego sat up for the first time Nov. 8. His 17-year-old brother, Peter Jr., placed headphones on his ears, letting him listen to a favorite ’90s hip-hop group, Atmosphere. Griego’s lips mouthed the words of the songs, and Griego squeezed his younger brother’s hand when he wanted the tune changed.

Wanek said she expected Griego to make a full recovery, “in that he will go home and live a normal life. He just needs to get used to having a lot less lung.”

Griego was eventually flown to Brooke Army Medical Center in San Antonio, where he began physical therapy. He regained the ability to speak on his own last week, and this week he will join his family at the Fisher House to eat turkey and celebrate Thanksgiving.

“It’s my favorite holiday because all of my family is there,” he said. “This time it’s going to be my immediate family and the wounded soldiers and their families. But I definitely think this Thanksgiving will mean the most to me.”

Afterward, his recovery will continue. His legs are weak, but he has started to walk with the help of a family member or a walker.

“I still get winded just sitting up. I yawn like a baby, and when I need to take a deep breath I can tell that it’s not all there,” he said of his missing lung.

None of the doctors have been able to tell Griego precisely what physical limitations he can expect, beyond acknowledging that he will likely not run a marathon anytime soon.

“I think everybody is still amazed that I made it,” he said. “And they are just as curious as me.”

The only family member still unaware of Griego’s injuries and miraculous recovery is his 4-year-old daughter, Rylie.

“I haven’t called her because I’m not sure what I want to tell her,” he said. “But her mother told me she says a prayer for her daddy and his Army buddies every night.”

robbinss@estripes.osd.mil
see more at
http://www.stripes.com/family-thankful-for-medical-innovation-and-for-a-soldier-s-survival-1.126242?localLinksEnabled=false